HSP47: Alternate Names

There are several alternate names associated with Hsp47. Hsp47 is a unique procollagen-specific molecular chaperone of the clade H of serpins (serine proteinase inhibitors) although it does not exhibit serine proteinase inhibitory activity. Consequently, the preferred name is Serpin H1. Hsp47 has also been named as gp46 in rats and J6 in mice, respectively ³⁶. Since this molecule was originally characterized as a 47 kDa membrane glycoprotein whose expression is induced upon heat shock, Nagata et al. suggested it may be referred to as Hsp47 ¹⁵. Due to its (pro)collagen-binding properties, Hsp47 can also be designated as collagen-binding protein 1 (CBP-1) or colligin-1, respectively. Alternate protein names also include arsenic-transactivated protein 3 (AsTP3), cell proliferation-inducing gene 14 protein, rheumatoid arthritis-related antigen RA-A47, collagen-binding protein 2 (CBP-2) or colligin-2; serine proteinase inhibitor, clade H, member 1 or -2. Gene aliases comprise HSP47, SERPINH1, CBP1, CBP2, PIG14, and SERPINH2 (Table 3).