HSP47: Tables

Table 1: Human and mouse orthologs of Hsp47 (Serpin H1)

  Human Mouse
Entrez Gene 871 12406
Ensembl ENSG00000149257 ENSMUSG00000070436
UniProt P50454 P19324
Reference sequence (mRNA) NM_001207014.1

NM_001235.3

NM_009825.2

NM_001111043.1

NM_001111044.1

NM_001285776.1

Reference sequence (Protein) NP_001193943.1

NP_001226.2

 

NP_033955.2

NP_001104513.1

NP_001104514.1

NP_001272705.1

Gene locus Chr11:75,562,056-75,572,783 Chr7:99,345,376-99,353,239
Pfam PF00079 PF00079

 


Table 2a: The clade A of the human Serpin superfamily of proteinase inhibitors

Protein UniProt ID Aliases Length (aa) Chromosome Gene ID
Clade A
Serpin A1 P01009 a1-antitrypsin, a1-protease inhibitor (a1-PI) 418, 359, 306 14q32.13 5265
Serpin A2 P20848 putative a1-antitrypsin-related protein 420 14q32.13 390502
Serpin A3 P01011 a1-antichymotrypsin, cell growth-inhibiting gene 24/25 protein 423, 216, 95 14q32.13 12
Serpin A4 P29622 Kallistatin, kallikrein inhibitor, peptidase inhibitor 4 427 14q32.13 5267
Serpin A5 P05154 Plasma serine protease inhibitor, plasminogen activator inhibitor 3 (PAI-3), protein C inhibitor (PCI) 406 14q32.13 5104
Serpin A6 P08185 Corticosteroid-binding globulin (CBP), transcortin 405 14q32.13 866
Serpin A7 P05543 Thyroxin-binding globulin, T4-binding globulin 415 Xq22.3 6906
Serpin A7P1   Pseudogene Xq22.3 100422644
Serpin A8 P01019 Angiotensinogen (AGT) 485 1q42.2 183
Serpin A9 Q86WD7 Centerin, germinal center B-cell-expressed transcript 1 protein (GCET1), serine proteinase inhibitor A11 417, 335, 201, 334, 286, 337, 435 14q32.13 327657
Serpin A10 Q9UK55 Protein Z-dependent protease inhibitor (PZI) 444 14q32.13 51156
Serpin A11 Q86U17 Antiproteinase-like 2 422 14q32.13 256394
Serpin A12 Q8IW75 OL-64, visceral adipose tissue-derived serine protease inhibitor (vaspin) 414 14q32.13 145264
Serpin A13P Pseudogene 14q32.13 388007
Serpin A15P Pseudogene 8q23.3 101930744

 


Table 2b: The clade B of the human Serpin superfamily of proteinase inhibitors

Protein UniProt ID Aliases Length (aa) Chromosome Gene ID
Clade B
Serpin B1 P30740 leukocyte elastase inhibitor (LEI), monocyte/neutrophil elastase inhibitor (EI), peptidase inhibitor 2 (PI-2), epididymis luminal protein 57, epididymis secretory protein Li 27 379, 228 6p25.2 1992
Serpin B2 P05120 Plasminogen activator inhibitor (PAI-2), urokinase inhibitor, placental plasminogen activator inhibitor 415 18q21.33-q22.1 5055
Serpin B3 P29508 Protein T4-A, squamous cell carcinoma antigen 1 (SCCA-1) 390, 338 18q21.33 6317
Serpin B4 P48594 Leupin, peptidase inhibitor 11 (PI-11), squamous cell carcinoma antigen 2 (SCCA-2) 390 18q21.33 6318
Serpin B5 P36952 Maspin, peptidase inhibitor 5 (PI-5) 375, 231 18q21.33 5268
Serpin B6 P35237 Cytoplasmic antiproteinase (CAP), peptidase inhibitor 6 (PI-6), placental thrombin inhibitor 376 6p25.2 5269
Serpin B7 O75635 Megsin, TP55 380, 363 18q21.33 8710
Serpin B8P1   Pseudogene 6p25.2 11029
Serpin B9 P50453 Cytoplasmic antiproteinase 3 (CAP-3), peptidase inhibitor 9 (PI-9), testicular tissue protein Li 180 376 6p25.2 5272
Serpin B9P1   Pseudogene 6p25.2 221756
Serpin B10 P48595 Bomapin, peptidase inhibitor 10 (PI-10) 397 18q22.1 5273
Serpin B11 Q96P15 Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11 392, 305, 190 18q21.33 89778
Serpin B12 Q96P63 Yukopin, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12 405, 425 18q21.33 89777
Serpin B13 Q9UIV8 Headpin, HaCaT UV-repressible serpin (hurpin), UV-B repressed sequence (HUR7), peptidase inhibitor 13 (PI-13) 391, 339 18q21.33 5275

 


Table 2c: The clades C – I of the human Serpin superfamily of proteinase inhibhitors

Protein UniProt ID Aliases Length (aa) Chromosome Gene ID
Clade C
Serpin C1 P01008 Antithrombin-III (ATIII), serpin peptidase inhibitor clade C member 1, antithrombin 464 1q25.1 462
Clade D
Serpin D1 P05546 Heparin cofactor 2,  HC-II, protease inhibitor leuserpin-2 (HLS-2) 499 22q11.21

 

3053
Clade E
Serpin E1 P05121 Plasminogen activator inhibitor 1 (PAI-1), endothelial plasminogen activator inhibitor 402, 387 7q22.1 5054
Serpin E2 P07093 Glia-derived nexin (GDN), peptidase inhibitor 7 (PI-7), protease nexin 1 (PN-1) 398, 397, 409 2q36.1 5270
Serpin E3 A8MV23 Nexin-related serine protease inhibitor; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 424, 404 13q14.3 647174
Clade F
Serpin F1 P36955 Pigment epithelium-derived factor (PEDF), EPC-1, cell proliferation-inducing gene 35 protein, testis tissue sperm-binding protein Li 70n  418 17p13.3 5176
Serpin F2 P08697 a2-antiplasmin (a2-AP), a2-plasmin inhibitor (a2-PI) 491, 427 17p13.3 5345
Clade G
Serpin G1 P05155 Plasma protease C1 inhibitor (C1Inh), C1 esterase inhibitor, C1-inhibiting factor, complement component 1 inhibitor, epididymis secretory sperm binding protein 500, 448, 505 11q12.1 710
Clade H
Serpin H1 P50454 47 kDa heat shock protein (Hsp47), arsenic-transactivated protein 3 (AsTP3), cell proliferation-inducing gene 14 protein, collagen-binding protein 1/-2 (CBP-1/-2), colligin-1/-2, rheumatoid arthritis-related antigen RA-A47, gp46, J6 418 11q13.5 871
Serpin H1P1 Pseudogene 9p13.3 158172
Clade I
Serpin I1 Q99574 Neuroserpin, peptidase inhibitor 12 (PI-12), serpin peptidase inhibitor clade I member 1 410 3q26.1 5274
Serpin I2 O75830 Pancpin, myoepithelium-derived serine protease inhibitor, pancreas-specific protein TSA2004, peptidase inhibitor 14 (PI-14), serpin peptidase inhibitor clade I  member 2 405 3q26.1 5276

 


Table 3: Hsp47/Serpin H1 of various vertebrates

Protein UniProt ID Aliases Gene names Gene ID
Human    
Serpin H1 P50454 47 kDa heat shock protein (Hsp47), arsenic-transactivated protein 3 (AsTP3), cell proliferation-inducing gene 14 protein, collagen-binding protein 1/-2 (CBP-1/-2), colligin-1/-2, rheumatoid arthritis-related antigen RA-A47 HSP47, PIG14, SERPINH1, CBP1, CBP2, SERPINH2 871
 
Mesocricetus auratus (Golden hamster)

 

Serpin H1 A0A1U7QK99 Hsp47; serpin peptidase inhibitor, clade H, member 1 Serpinh1 101829082
 
Alligator mississippiensis (American alligator)

 

       
Serpin H1 A0A151M3U0 Hsp47; serpin peptidase inhibitor, clade H, member 1 SERPINH1, HSP47 102561378
 
Amazona aestiva (Blue-fronted Amazon parrot)
Serpin H1 A0A0Q3X7T8 Serpin family H member 1 AAES_10215 ?
 
Oryzias latipes (Japanese medaka)

 

uncharacterized

protein

H2MH48 Hsp47, serpin family H member 1 Serpinh1, hsp47, cb216, fc56b02 100529194
Poecilia formosa (Amazon molly)

 

Serpin H1a A0A087X795 Hsp47; serpin peptidase inhibitor, clade H, member 1a Serpinh1 103145372
Danio rerio (Zebrafish)

 

Serpin H1a A8WFU6 Hsp47; serpin peptidase inhibitor, clade H, member 1a Serpinh1a 555328
Ceratitis capitata (Mediterranean fruit fly)

 

 
Serpin H1 W8BRM5 Heparin cofactor 2, serine protease inhibitor 27A LOC101457426

Serph

101457426

 


Table 4: Inhibitors and Modulators of Hsp47 (Serpin H1)

Agent References
Natural compounds and derivatives
Artesunate (butanedioic acid) Wang et al. (2015) 260, Lv et al. (2018) 261
Curcumin Pillai et al. (2014) 248, Ali et al. (2014) 252
Emodin (6-Methyl-1,3,8-trihydroxyanthraquinone) Chen et al. (2009) 254, Guan et al. (2016) 255
Gingerol Pillai et al. (2014) 248, Algandaby et al. (2016) 256
Lactoferrin Tung et al. (2014) 251, Rizk et al. (2018) 250
Resveratrol Ikeda et al. (2013) 253, Pillai et al. (2014) 248
Silymarin Pillai et al. (2014) 248, Rizk et al. (2018) 250
Xantholipin Terui et al. (2003) 258, Winter et al. (2013) 257
Small-molecule chemical inhibitors  
4 Compounds Thomson et al. (2005) 238
AK778, Col003 Ito et al. (2017) 244
Peptides
LDSRYSLQAAMYMRM Li et al. (2008) 246, Elias et al. (2014) 247
Calcium channel blockers
Amlodipine (Norvasc®) Honma et al. (2016) 262
Non-steroidal anti-inflammatory drugs (NSAIDs)
Meloxicam Honma et al. (2014) 263
Thromboxane/prostaglandin endoperoxide receptor antagonists
Terutroban (1-naphthalene-propanoic acid) Chamorro et al. (2009) 271, Gelosa et al. (2014) 266

 

Receptor tyrosine kinase inhibitors
Nintedanib (Ofev®) Wollin et al. (2015) 267, Hughes et al. (2016) 269, Knüppel et al. (2017) 270, Fletcher et al. (2018) 268
Miscellaneous uncategorized agents
Pirfenidone (Esbriet®)

5-methyl-1-phenyl-2-(1H)-pyridone

Nakayama et al. (2008) 273, King et al. (2014) 277, Lancaster et al. (2016) 276, Cottin et al. (2018) 275